Investigators said Jackson, 26, and his Uber driver, 54-year-old Jeffrey Monroe, were standing outside Monroe's vehicle along Interstate 70 when they were struck early Sunday by a pickup truck driven by Orrego-Savala.
Manuel Orrego-Savala, 37, had been deported twice - in 2007 and 2009 - according to Indiana State Police.
As was previously reported, Orrego-Savala had been previously deported out of the USA on two separate occasions.
Manuel Orrego-Savala remained jailed Tuesday following a court appearance in Indianapolis.
Police reveal the suspected drunk driver who struck a auto carrying Indianapolis Colts linebacker Edwin Jackson had been deported twice.
Jackson started in eight games with the Colts in 2016.
The affidavit said he has had prior run-ins with law enforcement for driving without a valid license and that he was walking away from the crash scene when an IN state trooper detained him.
The office of Marion County prosecutor Terry Curry filed the charges Wednesday. Collectively, Orrego-Savala is facing well-over a decade in prison if he is convicted.
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"May God comfort the family of Edwin Jackson who was killed by a drunk illegal alien who never should have been here", Gosar tweeted Monday.
Orrego-Savala fled the scene but was arrested shortly afterward. He faces up to 10 years in prison on the immigration charge, which the US attorney's office said would be handled after any state charges are resolved.
National Football League fans are still reeling from the tragic death of Indianapolis Colt's player Edwin Jackson, and now the suspect allegedly responsible for the fatal auto accident that killed him has been charged with multiple felonies. Federal and county prosecutors spell his name as "Orrego-Zavala" in charging documents, but his attorney said his name is spelled Orrego-Savala, a spelling listed among his aliases in the federal documents. Both men got out of the vehicle and were struck by the pickup. Jackson and Monroe were pronounced dead at the scene.
Just learned about the passing of one of my favorite teammates. He had entered the U.S. illegally in July 2004 and he was convicted of driving under the influence in Redwood City, California, in 2005, ICE said.
Trump went on to offer condolences to Jackson's family, and called him a "wonderful young man".
Investigators said they believe Orrego-Savala, who lives in Indianapolis, was intoxicated and driving without a license.
Trump was not the only GOP politician to use Jackson's death to renew calls for increased security along the southern US border with Mexico.
Orrego-Savala remains jailed in Indianapolis.