At least two people were killed and another 10 were seriously injured in a train crash near Milan early this morning.
The line links Milan and the northern city of Cremona.
Two carriages came off the rails, coming to rest at an angle.
The train, operated by state-owned company Ferrovie Dello Stato, crashed in Pioltello, near Milan. It happened just before 07:00 (06:00 GMT).
Television images showed injured survivors being evacuated, the more serious receiving first aid in a field close by.
"There at present are three dead, five extremely injured and eight injured in 'code yellow, ' all of which in doctor's facility", an Interior Ministry in Milan representative told Reuters.
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Footage from the scene showed that only the central carriages derailed, suggesting that the accident may have been caused by a malfunctioning railway switch.
Firefighters can also be seen trying to free people from the wreckage.
The head of Milan police said an investigation had been opened, with railway police interrogating the train driver.
Witnesses said the train trembled for a few minutes before the accident.
It is not yet clear what caused the crash.
In 2016, 23 people were killed when two trains collided on a single track in an olive grove in Puglia, south-eastern Italy.