With striker Alvaro Morata absent due too a back injury, Antonio opted to keep reserve strikers Michy Batshuayi on the bench.
"We must be very realistic to understand that this league is very risky", Conte, whose side lost 1-0 at struggling West Ham United on Saturday, told a news conference.
Danny Drinkwater missed the last game away to West Ham United with a virus, but he is be back to face Huddersfield.
Being free of European commitments in 2016-17 allowed Conte to focus all of his efforts on a successful title bid, but greater rotation is required this year with Champions League football back on the agenda.
The La Liga club have progressed from six of their past seven Champions League knockout ties against English opposition - the exception being their 2012 semi-final defeat by Chelsea, when the London club went on to lift the trophy.
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Efficiency improvements in the batteries also liberate an extra 12bhp from the electric motor , which powers the front wheels. The rear window doubles as a wind deflector can also be closed or opened independently without the roof.
United are second in the Premier League but are a whopping 11 points behind City and know despite the heavyweight teams left in the competition, the Champions League is probably a more realistic chance of silverware.
"They got the early goal, which was a poor one on our behalf".
But while Conte concedes his side's defeat to Manchester City was understandable, their losses to Burnley, Crystal Palace and West Ham, the latter two both in relegation danger, have given the Blues boss major cause for concern.
"The way we get in people's faces, we stop people playing, we win our tackles, we win our battles, we make it hard for teams".
He said: 'We have to fight until the end. We do have loads of games - but if we played to our levels today we get something out of the game. The last 16 is a good moment to play such teams.
The Brazilian winger laid the ball off for Pedro Rodriguez to score the third in the 50th minute as Chelsea cut through Huddersfield at will.