A joint report from the United Nations and worldwide chemical weapons inspectors last month determined the Syrian regime of Bashar al-Assad was responsible for the attack.
It remained unclear whether Russian Federation would veto the US-drafted measure, which would be the 10th time that Moscow has used its veto power at the council to block action targeting its Syrian ally.
The vote is scheduled for 2000 GMT, just hours before the mandate of the so-called JIM expires at midnight.
Russian Federation cast its 10th veto on Thursday of United Nations Security Council action on Syria since the war began in 2011, blocking a US-drafted resolution to renew an global inquiry into who is to blame for chemical weapons attacks in Syria.
The President affirmed that Syria has adopted the right policies in the face of those followed by some regional and Western countries that have sought to achieve their interests through spreading chaos in and disrupting the stability of an important and sensitive region like the Middle East without considering the disastrous results that may ensue from that.
Russian President Vladimir Putin will next week host Turkish and Iranian counterparts Recep Tayyip Erdogan and Hassan Rouhani for summit talks on Syria, Turkish state media said today.
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"Everyone in the Security Council would be shooting ourselves in the foot if we allowed that to happen", he said.
The United States and Russia, Syria's ally, have put forward rival draft resolutions on renewing the mandate of the Joint Investigative Mechanism (JIM), tasked with investigating Syria's toxic gas attacks.
Turkish, Russian and Iranian foreign ministers will meet in Turkey's Mediterranean city of Antalya at the weekend ahead of a trilateral meeting on Syria in Russia's Sochi city next Wednesday, Turkish foreign minister has said.
The JIM's leaders said they were "confident" that Syria's government was responsible for an aerial attack on Khan Sheikhoun on April 4 using sarin that killed about 100 people and affected about 200 others who survived "acute exposure" to the nerve agent.
While Russia agreed to the 2015 creation of the JIM, it has consistently questioned its findings, which also concluded that the Syrian government used chlorine as a weapon several times.
French Ambassador Francois Delattre urged council members to "please think twice before throwing it away, because this would be a major setback for the fundamentals of our common security".