Burnley's club record signing, until Chris Wood arrived, Cork represents an upgrade on what was in Burnley's engine room previously. A convincing win could see them climb seven places up the table, and the poor form of Palace will give them hope of achieving it.
It means Palace have lost all four of their Premier League matches since De Boer took over in the summer, without scoring a goal, and the Dutchman appears to be under considerable pressure.
However, the Dutch coach insists it remains business as usual in the club's "long-term" vision.
Burnley return to league action after the worldwide break in good spirits having earned a hard-fought point against Tottenham Hotspur last time out.
In this match Lee Chung-yong could become the third South Korean player to make 100 Premier League appearances, after Park Ji-Sung and Ki Sung-yueng.
And the August signing wasted no time in making his mark at his new home, giving the Clarets the flawless start.
It took just three minutes for Wood - making his first start for Burnley following his summer move from Leeds - to open the scoring, with the goal put on a plate for the New Zealand worldwide.
Wood reacted superbly, intercepting the pass and slotting past Palace goalkeeper Wayne Hennessey first time from the edge of the area.
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Then, in the 89th minute, Palace defender Scott Dann was presented with a virtual open goal but he headed wide.
Indeed, Palace remain the only team across England's top four divisions who are yet to score this season, although Scott Dann missed a glaring opportunity to change that statistic in the closing stages, while De Boer's early tenure is ominously reminiscent of the poor start that saw him sacked by Inter in November a year ago.
The visitors dominated after the restart, but for all the play they had in Burnley's half there were few clear chances created.
"We showed spirit", De Boer said.
Jeffrey Schlupp was given a sight of goal with 20 minutes to go after the Clarets had seen off another corner but the defender lashed his effort over the bar and moments later his side almost conceded again. The Belgian striker burst through on goal but saw his effort from 8 yards out saved by Burnley's backup keeper.
Palace have started the Premier League with three straight losses - at against Huddersfield and Swansea, and at Liverpool - and have yet to score a goal.
For both Leeds and now Burnley, Wood has been on fire in 2017.