Alabama wide receiver Calvin Ridley makes a catch.
Francois, who started every game for Florida State last season, was one of the main reasons the Seminoles were ranked high to start the season.
Harris powered through the middle into the end zone on the next play, and a two-point-conversion pass from Jalen Hurts to Calvin Ridley gave the Crimson Tide a 21-7 with 1:41 remaining in the third.
"As the game went on, I feel like we wore them down and were able to execute the way we wanted to".
The sophomore was injured during the Seminoles' season-opening 24-7 loss to Alabama on Saturday.
The two biggest questions concerning Alabama entering this season were the development of Hurts as a passer and how effective the Tide could be from a pass-rushing standpoint after losing outside linebackers Ryan Anderson and Tim Williams to the NFL.
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"This was obviously a great team win for us", Saban said.
Terrell Lewis broke into the backfield to stop Florida State's George Campbell for a 4-yard loss on first down.
It is the nature of the sport for the quarterbacks to get the majority of the attention, but for all the time the media spent on Francois and Alabama's fellow super sophomore quarterback Jalen Hurts prior to (and during) the game, it was the Tide's duo of versatile defensive back Minkah Fitzpatrick and run-stuffing defensive tackle Da'Ron Payne who easily made the biggest splashes from an National Football League draft perspective.
On the same play that Florida State was called for pass interference, Alabama's sideline was hit with a delay of game penalty.
Francois earned ACC Rookie of the Year and ACC Offensive Rookie of the Year honors in 2016, leading all freshman QBs with 3,350 yards and 20 touchdowns. Including a 53-yard touchdown in which he shook FSU true freshman cornerback Stanford Samuels III with a classic stutter step, before racing past him to haul in a flawless strike from Hurts.
Florida State took its second drive 90 yards on 11 plays and grabbed a 7-3 lead on a 3-yard touchdown pass from Francois to Auden Tate at the 13:41 mark of the second quarter. On the FSU kick attempt, Minkah Fitzpatrick pushed through the Seminoles' line to block the attempt and keep the score locked at 10-7 heading into halftime. Late in the fourth quarter, Tide linebacker Ronnie Harrison sacked quarterback Deondre Francois from behind while he was rolling out.
Less than a minute later, the Tide took back the ball again when Levi Wallace picked off Francois' pass at the FSU 42-yard line.
Alabama will open its home schedule this Saturday against Fresno State.