However, the home fans celebrated the first goal of this bruising contest just before the half hour with Nigeria never looking back to seal an important win.
Even one Group B point in Yaounde would send Nigeria to Russian Federation, if Zambia and Algeria draw twice.
"I watched the game against the Cameroonians on Friday and I am sure you have the ability to conquer them again in their own territory".
Mikel scores the second goal.
Tried as the Indomitable Lions did, Nigeria's goal keeper Ezenwa had the needed confidence to save sticky situations for the Super Eagles.
"Against Nigeria, we must play as a team and do the basic things, play easy and simple football".
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The Eagles are now unbeaten in 33 World Cup qualifying games.
Perhaps, substitute Iheanacho failed to read the script that the Eagles were playing the African champions, and chose to head the fourth from a sublime Ogenyi Onazi pull -out with 13 minutes left.
Nigeria are sitting pretty in Group B - branded the "group of death" - with a maximum nine points from three matches.
A delighted Coach Gernot Rohr praised his team and said they were dedicating the victory to recuperating goalkeeper Carl Ikeme.
Uganda are top of the group on seven points after yesterday's 1-0 win over Egypt, who are second on six points.
More work lie ahead for the Super Eagles who will battle Cameroon in a return leg on Monday, September 4, 2017, at the Ahmadou Ahidjo Stadium, Yaoundé.