That includes a Friday-Sunday take of $45.3 million.
The most recent "Transformers" film, "The Last Knight", opened on Wednesday to lackluster results. Last Knight earned a B+ on CinemaScore, the only film in the series apart from 2009's Revenge of the Fallen to not earn an A or A-, which usually signifies not only whether a film is popular with moviegoers, but also if it has staying power in the box office top 10. Imax theaters contributed $24.3 million.
However the movie, starring Mark Wahlberg, Laura Haddock, Anthony Hopkins and giant mechanical robots, went down well overseas. When the government receives information that a new alien threat may yet again mean the destruction of the Earth, the military makes a deal with the Transformers to locate an ancient hidden weapon, which turns out to be Merlin's staff and their only hope of survival.
Michael Bay's billion-dollar Transformers franchise has another chapter - this time with Oscar-winner Sir Anthony Hopkins helping to headline the cast.
The fifth and latest movie in the franchise, The Last Knight, attempts to fix that problem.
Ahead of the weekend, the film has an audience rating of about 62 percent.
After a month in release, the DCEU film is expected to land in the number three spot once the weekend is said and done.
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The movie sees Mark Wahlberg return as inventor Cade Yeager in a world where humans are warring against the titular robots - and Optimus Prime is gone.
Patty Jenkins' "Wonder Woman" continued its strong performance in box office, becoming the top-grossing live-action film directed by a woman. The superhero tentpole earned an impressive $25.2 million to cross $300 million domestically.
"Wonder Woman" and "Cars 3" tied for second place, each claiming $25.1 million this weekend. We considered the highest gross revenue figures adjusted to 2017 dollars for the 186 franchises with data from Box Office Mojo.
While the weak domestic opening for The Last Knight is no doubt cause for concern for Paramount, the studio should be able to take comfort in the film's reception overseas - which will help push the first weekend global tally of the film far into the $200 million range (initial estimates had the film grossing anywhere from $237.5 million to $270 million).
Despite North American numbers being low, the franchise is hoping for worldwide success.
In limited release Kumail Nanjiani's acclaimed romantic comedy "The Big Sick" landed the best per-screen average of the year. The film, which opened in limited release, has brought in an estimated $435,000 from five locations with a per-screen average of $87,000. From a script by Kumail Nanjiani and his now-wife, Emily Gordon, the film draws from their real-life courtship and revolves around a young Pakistani comedian (Nanjiani) and his American girlfriend (Zoe Kazan) who must contend with their cultural differences (and two very different sets of parents) when she becomes gravely ill.