The first two films in the "Cars" franchise have reflected the growing clout of markets overseas.
The animated sequel made its debut with sales of $53.5 million in the US and Canada, researcher ComScore Inc. estimated Sunday in an email.
"Wonder Woman" finished in second place with an estimated $40.7 million, bringing its domestic total to just below $275 million.
The Tupac Shakur biodrama, All Eyez on Me, was third with $27-million. "Rough Night", $8.1 million 8. The film has also claimed the title of the eleventh-biggest third box office weekend of all time for any film, in terms of domestic numbers.
The "Cars" threequel follows the legendary Lightning McQueen (Owen Wilson) as he's pushed out of the sport he loves by a new generation of blazing-fast racers.
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The movie is the directorial venture of Brian Fee, who worked as a storyboard artist on Cars and Cars 2, as well as Ratatouille and Wall-E.
"Once again flying past expectations and topping high-end estimates, Warner Bros.' latest DCU entry Wonder Woman's third weekend in release is another one for the record books", wrote Mark Hughes in Forbes. Titled after Shakur's 1996 fourth studio album of the same name, the film stars Demetrius Shipp Jr.as Shakur and Kat Graham, Lauren Cohan, Hill Harper, and Danai Gurira in supporting roles.
With 55 percent positive reviews, the other new wide release was the shark-diving horror thriller "47 Meters Down".
"It is genuinely a amusing movie that was made at the right price, and there is a place for Rough Night as summer counter-programming in the coming weeks", said Sony's distribution chief Adrian Smith.
In terms of the DCEU, Wonder Woman now trails Man of Steel ($668.0 million), and while it will certainly face some stiff competition this coming week from Transformers: The Last Knight, it's still possible that the Amazon Princess' solo debut could overtake the Superman reboot. Lucia Aniello directed the film.