A city spokesman said that passengers were killed and injured in the wreck, but was not able to specify how many.
A train has collided with a charter bus at a railroad crossing on Main Street in Biloxi, Mississippi.
A MS, hit a charter bus that appeared to be stuck on the tracks Tuesday, according to local outlet WLOX.
"It's a awful, chaotic scene", Miller said.
The accident happened at around 2.00pm local time (8.00pm Irish time).
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Creel says he doesn't know where the bus was headed but charter buses often carry people to casinos in Biloxi, according to the AP.
Witnesses said the passengers on the bus were senior citizens.
Rescuers have been removing trapped passengers through emergency windows, and at least one person has been taken to hospital by air ambulance.
CSX, based in Jacksonville, Florida, didn't immediately respond to a request for comment.
NBC News reports the bus was traveling from Austin, Texas. The company has yet to make a statement about the incident. According to the Associated Press, the CSX train pushed the bus for about 300 feet before coming to a stop.