Proverbial lightning struck for a second time on Saturday night in Acapulco, as Sam Querrey played essentially flawless tennis to win the second 500 title of his career by defeating Rafael Nadal in the final, 6-2, 7-6 (3).
Mladenovic made it into her second final of the year, holding off fifth-seeded American Christina McHale 7-5, 4-6, 6-2.
Murray was at his impressive best against Fernando Verdasco, who could not cope with the brilliance of the Scot. Murray did not take much time as he won the match in straight sets - 6-3, 6-2 - with the final lasting for 73 minutes only.
Live streaming: The matches can be watched online on Tennis Channel Live, StarHub Go.
"He played very well, nearly reaching perfection", Nadal said.
"Reaching the final in two of the three tournaments I have played [this year] is good". Sam is playing great.
"Anytime you play against someone like Cilic you expect to suffer in a tight match, but it was not like that", Nadal said.
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The 30-year-old Nadal, who reached his first Grand Slam final in almost three years at January's Australian Open, was looking to win his first hard-court title since January 2014, when he took the trophy at the Qatar ExxonMobil Open. "I hope I can have more like this", Querrey said.
With games at 6-5 and on serve in the third set, Querrey then broke the Kyrgios serve to triumph 3-6 6-1 7-5.
He's the first American champion in the history of the event.
The 21-year-old Australian beat Nadal in Wimbledon (2014) and Federer in Madrid (2015).
A delighted Krygios said that he doesn't change his game when he meets top players.
The American had a great week beating favored players on the road to the championship. "The ball bounces right into my strike zone on these courts, so I'm very comfortable playing here".
Querrey had 19 aces to win his ninth career title.