Indianapolis Colts: Week 3 Preview vs

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They limited Demaryius Thomas and Emmanuel Sanders to less than 100 yards combined in their season opener. "We've won a handful of games against the Colts but, shoot, not this team".

Gates has long operated as one of Philip Rivers' top receiving threats, but his target share has steadily decreased each of the past two seasons.

Become the 27 team since 1990 to start a season 0-2 and still make the playoffs.

Right now, Rivers is playing some of the best football of his career. They are equally terrible against both the run and the pass, ranking 31st in the league in both categories.

Editor's note: NESN.com's Mike Cole, Ricky Doyle and Andre Khatchaturian deliver their National Football League picks every Thursday of the season, and here's who they like in the San Diego Chargers-Indianapolis Colts Week 3 game, with the line from OddsShark. In two games, the Raiders lead the league in passing yards allowed per game with a whopping 404-yard average.

It was a first half of mixed results from Luck, as he completed 11 of 18 passes for 143 yards but also had the two turnovers.

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San Diego quarterback Philip Rivers versus the Colts defense: Rivers hasn't thrown an interception in 88 pass attempts this season. A last-second loss to Detroit opened the season, only to see the Colts offense overwhelmed on the road by the Broncos.

Once again, Luck and the offense looks like they will have to carry the club. Melvin Gordon has already run for 159 yards and three rushing touchdowns.

"That's a team that has had great success early in games, " defensive coordinator Ted Monachino said. "We're going to manage him the way we manage all of our players and try to make sure we get them to Sunday as healthy as possible", said head coach Chuck Pagano on Friday in regards to the speculation on Luck's health. The only touchdown of the game came early in the second quarter, where rookie Keenan Allen, beat Colts cornerback, Vontae Davis, on a post pattern for a 22 yard touchdown.

Contain Colts' deep speed: With Donte Moncrief out with a shoulder injury, Indianapolis will lean on T.Y. I do remember it being the last game there in that dome, which makes it even more special.

Both the Bills and Chargers will look for other playmakers on their rosters to step up in the absence of two of their biggest offensive weapons, as both seem unlikely to play in Week 3. This matchup is all about the quarterback.

It was mentioned the topic of discussion is Andrew Luck, who signed an extension in June that will pay him almost $140 million through 2021.

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